About the Journal

Translational Medicine and Exercise Prescription (TMEP) is an international Open Access, peer-reviewed, academic journal, aiming to bridge the gap between mechanistic research and exercise prescription models. The Journal is bringing together the fields of exercise biology, sports medicine and science of physical training and testing.

The journal will consider manuscripts from a wide range of translational research performed in humans, which includes aspects of exercise prescription based on mechanistic approaches and provides clinical applications of exercise evaluation and therapy in health and chronic conditions. Original work submitted to the Journal should adhere to the FITT criteria (i.e. frequency, intensity, time and type of exercise) and should include clearly defined doses of physical exercise or activity, with the aim of optimizing the biological responses. Special consideration is given to novel types of exercise prescription, including technology-based intervention approaches. Moreover, TMEP encourages submissions of “negative findings” and (or) possible reports of harmful adverse events (e.g. if trials are terminated prematurely) as long as the quality of the study can be assured (i.e. indicated by relevance/novelty of the question, rigorous methodology, transparency and reproducibility). The specific themes are related to research focusing on the therapy and prevention of chronic diseases (i.e. obesity, diabetes, cancer, cardiovascular diseases, neurological and psychiatric diseases, pulmonary diseases, musculoskeletal diseases and endocrine disorders) or health and fitness maintenance.

The journal is using an online system for manuscript submissions, review and tracking. The manuscripts will be reviewed by Editorial Board members of Translational Medicine and Exercise Prescription and (or) outside experts through a single-blinded process. Acceptance of submitted manuscripts is depending on the positive votes of at least two independent reviewers and the acceptance of section and chief editors. Accepted papers will be published online immediately as "Just Accepted" in its accepted version (PDF) and in 2 weeks after acceptance fully edited.

The following article types may be considered for publication: Original articles, reviews and short communications. The journal publishes quarterly online, providing worldwide access to all content free of restrictions or other subscriptions.

TMEP SECTIONS

Manuscripts submitted to TMEP should be well in line with the general scope of the Journal outlined above. The followings provide a short introduction to each section of the Journal. If you are unsure whether your manuscript is suitable for publication in TMEP, please do not hesitate to contact the editorial staff.

Musculoskeletal disorders

The musculoskeletal system is the basis of all our movements. As such, it is important to mechanically understand the way it is working. The musculoskeletal system is also embedded into the body’s metabolic environment, both as a recipient as well as a supplier of energy and other metabolites. Moreover, cytokines from the muscles and from the bone are modulating the body’s inflammatory responses. Muscles, bones and other passive connective tissues are known to adapt to exercise stimuli, many of which will be of mechanical nature. However, it is currently not understood how the principle knowledge of biological responses can be transformed into exercise prescription. TMEP’s musculoskeletal section therefore aims to publish articles that have a solid foundation in basic science and that attempt to improve musculoskeletal health through physical interventions.  Where the principle effectiveness of an intervention type has already been demonstrated, new studies should aim at establishing dose-response relationships or at comparing the effectiveness of different interventions.

Obesity

The end of the last century saw a substantial increase of the occurrence of obesity related to inappropriate lifestyle changes. This phenomenon, which is related to comorbidities such as inflammation, type 2 diabetes mellitus and cancer, is ever more expanding. In order to counteract or prevent the onset of caloric intake- and physical inactivity-related obesity, intervening with the metabolic changes that lead to obesity is one of the priorities of modern medicine. Pharmacological interventions not seldom lead to undesired collateral effects. Physical exercise, being non-invasive and relatively low-cost, is one physiological approach to tackle this emerging problem. Individual genetic differences and dietary habits in humans can drastically influence the effectiveness of exercise programs, either or not in combination with nutritional interventions and/or mimetics. It has also emerged that exercise programs, in order to be consistently followed by the subjects, should be “tailored” to meet the demands of each individual. Prescribed exercise programs can be endurance exercise or resistance exercise, the latter has especially been recommended for elderly, because resistance exercise provokes less acute strain on the heart. This section deals with the development of specific obesity-counteracting exercise programs, either or not coupled with nutritional interventions, as well as the underlying mechanistic and molecular aspects. Single or multi-modal exercise approaches such as combined aerobic and strength training or other modalities, such as sprint-interval training or vibration training will be considered, provided that the training intervention is described in detail and well-justified.

Neurological and psychiatric diseases

Physical activity and regular exercise have clear health and well-being benefits for neurological and psychiatric conditions. Exercise prescription for these conditions has evolved rapidly over the last 20 years, and there is clearly exciting potential for exercise in both the prevention and treatment of these conditions. As the prevalence of these conditions grows globally, there is a need for international guidance and recommendations to be underpinned by evidence of exercise responses and recovery. Current research findings are often limited to average responses and the need for more individualized understanding of loading characteristics and subsequent dose-response relationships is critical in this area where disease and presentation are heterogeneous and disease trajectories vary. This section welcomes research evidence exploring mechanisms, and efficacy and effect where findings are underpinned by mechanistic research outlining responses of body systems such as metabolic, cardiovascular, respiratory, neurological, endocrine, immunological and musculoskeletal systems.  

Endocrine disorders

Manuscripts submitted under the Endocrine Disorders section of TMEP should have a central theme to the study design which deals with hormones and, or the endocrine actions of related biomarkers. Since the journal is translational in nature, it is important that mechanistic and, if appropriate, adaptative consequences of the hormonal responses be addressed. Furthermore, it is advised that factors which confound interpretations of endocrine actions (e.g., time of day, participant diet, environmental factors) be controlled for in studies, and addressed in the manuscript. If authors are uncertain if their manuscript meets these criteria, they are encouraged to contact the section editor prior to submission.

Cancer

For the TMEP Cancer section, we are dedicated to the exploration of exercise training as a treatment strategy in the oncology setting through the framework of clinical medicine. We publish novel and rigorous research aiming to investigate concise and targeted effects of exercise training throughout the cancer trajectory. We also welcome studies aiming to elucidate the complex biological perturbations following acute and chronic exercise in patients under influence of malignant disease and/or anti-cancer therapies. Priority is given to studies designed to provide evidence of the effects—both benefits and adverse reactions—of targeted exercise training programs, as well as elucidate possible underlying mechanisms, on ‘principal endpoints’ for cancer patients. These principal endpoints include outcomes that are disease-specific (e.g., survival and disease progression), treatment-related (e.g., tumor response and treatment tolerability), and health-related quality of life. Other outcomes, including physiological adaptations to exercise training, should, in principle, be considered surrogate markers, sub-domains or ‘intermediates’ of these principal endpoints. Papers examining such outcomes are welcome but should clearly outline the mechanistic, scientific, or theoretical rationale as to how these surrogates and intermediates are linked to the principal endpoints.

Diabetes

Diabetes is one of the most prevalent and costly chronic disease globally, in part because of its deleterious impact on whole body physiology and accelerated biological aging, leading to poor physical functioning, declining cardiorespiratory fitness with an elevated risk of frailty. Exercise-based interventions are one of the most efficacious at targeting the disease specific (e.g. insulin resistance) and whole body (e.g. poor physical function) phenotype of diabetes. However exercise-based therapies have been poorly translated into routine care pathways. This section welcomes articles that offer new insight into how exercise can be tailored (by manipulating the FITT criteria) to support optimal glycemic control or the whole body consequences of diabetes (type 1 or type 2), especially those related biological aging, including muscle function and structure and their clinical manifestations (sarcopenia and frailty), vascular and cardiac function, and wider biomarkers of cardiometabolic health. It is recognized that a range of methodologies can be used to address these research areas, therefore, observational and experimental designs are welcome; however it should be emphasized that human participants should be at high risk of, or diagnosed with, diabetes. We also strongly encourage the submission of studies that have evaluated exercise-based interventions or prescriptions within routine diabetes prevention or management pathways or clinical settings. Background medication status and any concomitant diets should be clearly stated and the potential impact of these on the study findings articulated.

Cardiovascular diseases

TMEP aims to publish the highest quality material, both clinical and scientific, on all aspects of exercise and cardiovascular medicine. In addition, the TMEP cardiovascular section provides a forum for the exchange of information on all aspects of cardiovascular medicine, including education issues. The general aim of the cardiovascular diseases section is to present a research-based view of the beneficial and adverse effects of physical activity, exercise training and rehabilitation on cardiovascular function and outcomes. The journal will publish research reports on the role of physical activity, exercise training and fitness in the prevention of diseases and the role of various kind of exercise interventions in the treatment or prehabilitation/rehabilitation of cardiovascular diseases and maintaining well-being. This includes in-depth investigations into the mechanisms that mediate the beneficial cardiovascular effects of exercise. The journal accepts research evidence on the metabolism, molecular mechanism, genetics and aging interaction with distinct and well-defined exercise interventions on cardiovascular function and vascular health. This aids in understanding the need for exercise interventions together with medical therapies and as a stand-alone therapy. The cardiovascular diseases section accepts a wide range of studies including advanced statistical methods focused on investigating lifestyle, exercise, fitness, as well as nutritional, environmental, and genetic aspects with new risk-stratification strategies, prevention, and treatment for cardiovascular diseases. It addresses the causes and prevention of cardiovascular disease, as well as cardiovascular rehabilitation and exercise physiology.

Pulmonary diseases

With aging of the population, the burden of diseases of the pulmonary system has risen dramatically, impacting patients, families, and health care systems. The clinical applications of exercise testing and training in pulmonary disease are generally dismissed in favor of more sophisticated and costly interventions, and these interventions tend to be the focus of most journals related to the respiratory diseases. However, much like cardiovascular disease and other chronic conditions, exercise tolerance powerfully predicts risk for adverse events in patients with pulmonary disease. Thus, efforts to apply exercise interventions to improve exercise capacity, symptoms, and quality of life in pulmonary disease are a critical part of the therapeutic paradigm. Exercise interventions have numerous other benefits in pulmonary disease, including musculoskeletal, cardiovascular, and psychosocial, and reductions in frailty and disability. Despite these benefits, only a small fraction of eligible patients with pulmonary disease are referred for exercise programs. A medium to help disseminate the value of exercise therapy to the clinical community in pulmonary disease is needed, and TMEP helps to fill this role. The vast majority of studies have focused on chronic obstructive pulmonary disease, but there is growing recognition of an important role for exercise intervention in lung cancer, lung resection, transplantation, pulmonary fibrosis, prehabilitation for surgical interventions, and many others. This section of the journal welcomes studies that further explore research in these areas.

Advanced exercise prescription and health

The TMEP section advanced exercise prescription and health aims at research that provides further insights into innovative training interventions that target health maintenance or improvement of the general population. Articles submitted to this section can include both cross-sectional and longitudinal study designs with outcomes related to fitness and health throughout the lifespan (i.e. including children and adolescents, adults and seniors). However, the performed exercise loading or training intervention needs to be described in detail and justified on a mechanistic basis. Studies that are performed in healthy populations with the aim to test a certain training method in order to be applied in clinical settings at a later stage are also published in this section as long as the rational for the intervention has been clearly stated. Studies performed in athletic populations may be considered for publication if the potential translation to other populations and settings is clearly outlined.

EDITORIAL EVALUATION TIMELINE

We read and evaluate every submission, and we try our best to get back to you quickly. We are mindful of the time it can take to publish a paper and work with authors and reviewers to minimize that time. Below you may find the approximate duration for each step of the editorial process:

Initial decision to review                                        3-5 days after submission

Decision after review                                             3-4 weeks after submission  

Anticipated timeframe for suggested revisions    4 weeks    

Time to online publication as “Just Accepted”      72 hours after acceptance 

Time to official online publication                         14 days after acceptance